Безпека лікарських засобів у стоматології: фактори ризику, побічні неалергічні реакції, фармаконагляд та практичні рекомендації

Kostiantyn Lykhota; Ganna Zaychenko; Oleksandr Grynevych; Oksana Simonova; Maryana Slobodyanik-Kolomoiets; Volodymyr Shmatko

doi:10.33295/1992-576X-2006-1-81

Authors

Kostiantyn Lykhota Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine https://orcid.org/0000-0003-0912-6470
Ganna Zaychenko Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0002-3506-4800
Oleksandr Grynevych Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0001-6542-8102
Oksana Simonova Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0002-7239-6193
Maryana Slobodyanik-Kolomoiets Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine https://orcid.org/0000-0002-7567-4136
Volodymyr Shmatko Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0001-5402-1905

DOI:

https://doi.org/10.33295/1992-576X-2006-1-81

Keywords:

dentistry, drugs, adverse reactions, prevention, pharmacovigilance, clinical cases, drug safety, non-allergic adverse reactions

Abstract

This article systematizes current concepts of drug safety in dentistry. It reviews the most common adverse reactions, the main groups of drugs, risk factors for their occurrence, clinical examples, and statistical data from international and national sources. The experience of Ukraine in the field of dental pharmacovigilance is highlighted. Practical recommendations are proposed to help dentists minimize the risk of adverse reactions and improve the safety of pharmacotherapy.
Purpose: to summarize contemporary scientific data on drug safety in dentistry, identify the main risk factors for adverse reactions, outline the principles of pharmacovigilance, and formulate practical recommendations for dental practitioners.
Materials and methods: scientific literature (PubMed, Scopus, Google Scholar), statistics from EudraVigilance, VigiBase, and the State Expert Center of the Ministry of Health of Ukraine were analyzed. Practical recommendations were developed to reduce the risk of adverse reactions.

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References

Dobrovynska, O., Khlyebas, S., Mazur, P., & Slobodianyk-Kolomoyets, M. (2023). Correlation between diabetes and periodontal diseases. Oral and General Health, 4(1), 20–23. [Добровинська О., Хлєбас С., Мазур П., Слободяник-Коломоєць, М. (2023). Взаємозв’язок цукрового діабету і захворювань тканин пародонта. Oral and General Health, 4 (1), 20–23]. DOI: https://doi.org/10.22141/ogh.4.1.2023.148. [in Ukrainian].

Buriak, R., Slobodianyk, M., & Pozur, T. (2022). Dental care for patients with cardiovascular diseases. Oral and General Health, 3(3), 16–20. [Буряк Р. В., Слободяник М. В., Позур Т. П. Стоматологічна допомога пацієнтам з серцево-судинними захворюваннями. Oral and General Health. 2022. Т. 3. № 3. С. 16-20. DOI: https://doi.org/10.22141/ogh.3.3.2022.127.

Хайтович М. В. Поліфармація: визначення, ризики, менеджмент. Oral and General Health. 2021. Т. 2. № 3. С. 7–12. DOI: https://doi.org/10.22141/ogh.2.3.2021.240720.

State Expert Center of the Ministry of Health of Ukraine. [Державний експертний центр МОЗ України.] URL: https://dec.gov.ua

Ministry of Health of Ukraine. (2006). Order of the Ministry of Health of Ukraine dated 27.12.2006 No. 898 “On approval of the procedure for monitoring adverse reactions of medicinal products permitted for medical use.” [МОЗ України. (2006). Наказ МОЗ України від 27.12.2006 р. № 898 «Про затвердження порядку здійснення нагляду за побічними реакціями лікарських засобів, дозволених до медичного застосування» (http://zakon2.rada.gov.ua/laws/show/z0073-07). URL: https://www.umj.com.ua/uk/publikatsia-86761-pobichni-reakcii-sprichineni-zastosuvannyam-nesteroidnix-protizapalnix-preparativ-analgetikiv-antipiretikiv

Avery, A. J. (2011). Polypharmacy: one of the greatest prescribing challenges in general practice. British Journal of General Practice. P. 83–84. DOI: https://doi.org/10.3399/bjgp11X556146.

Kotsalou, E. (2021). Polypharmacy in elderly people: epidemiology, consequences and prevention strategies. Mìžnarodnij endokrinologìčnij žurnal. No. 17(1). 56–62. DOI: https://doi.org/10.22141/2224-0721.17.1.2021.226432

WHO Uppsala Monitoring Centre. VigiBase reports. URL: https://who-umc.org

EudraVigilance database. URL: https://www.adrreports.eu/