Принципи спрямованої регенерації кісткової тканини у стоматології та щелепно-лицевій хірургії: еволюція концепції та біологічні механізми (огляд)
DOI:
https://doi.org/10.33295/1992-576X-2025-4-112Ключові слова:
спрямована регенерація кісткової тканини, бар’єрні мембрани, остеогенез, кісткові дефекти, щелепно-лицева хірургіяАнотація
Актуальність. Спрямована регенерація кісткової тканини (GBR) — це високоефективна методика відновлення кісткових дефектів, що широко застосовується у стоматології та щелепно-лицевій хірургії. Зростаючий попит на імплантаційне лікування стимулює розвиток високоефективних бар’єрних мембран.
Мета: узагальнити сучасні уявлення про принципи спрямованої регенерації кісткової тканини, висвітлити біологічні основи методу, етапів його історичного розвитку, біологічні механізми остеогенезу та ангіогенезу, а також оцінити перспективи використання нових бар’єрних матеріалів.
Матеріал і методи. Інформаційний пошук і аналіз наукових джерел здійснювали з використанням наукометричних баз даних Web of Science, PubMed, Google Scholar, Scopus, SpringerLink, ScienceDirect, Wiley Online Library, охоплюючи публікації за останні 50 років.
Висновки. Метод GBR забезпечує кероване та ефективне відновлення кістки шляхом ізоляції дефекту та стимуляції остеогенезу. Вибір відповідної мембрани залежить від клінічної ситуації, біосумісності та здатності до біодеградації. Інноваційні поліуретанові мембрани демонструють високий потенціал завдяки механічній стабільності та можливості функціоналізації. Майбутнє GBR пов’язане з інтеграцією молекулярних технологій, нових матеріалів та індивідуалізованого підходу до лікування.
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Посилання
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