Free radical activity and indicators of antioxidant protection of the blood with and without the use of a complex of antioxidant drugs
DOI:
https://doi.org/10.33295/1992-576X-2020-4-13Keywords:
ulcerative-necrotic gingivitis, experimental animals, API, MDAAbstract
Topicality. Periodontal diseases are among the most common dental diseases. This article highlights the results of a study of blood parameters in animals that underwent the simulation of ulcerative necrotic gingivitis and compared them with animals that under the same conditions received local treatment of this pathology with a developed complex of antioxidant drugs.
The aim of the study was to analyze the nature of changes in the state of the antioxidant-prooxidant system during the pathological process without and on the background of treatment, and investigated their impact on quantitative and functional indicators of markers of inflammatory intensity.
Materials and methods. The study was conducted on 18 rabbits. The model of ulcerous-necrotic gingivitis was obtained in animals by chemical burns. Experimental preparations were applied to the damaged gum area 2 times a day in 2 hours after feeding the animals at an approximate dose of 200 mg. The nature of the course of experimental ulcerous-necrotic gingivitis was investigated on the 3, 5, 7 and 10-th days of the healing process.
Results and discussion. The maximum increase in the concentration of MDA in the blood of animals of the experimental group was observed in the first observation period. In the next two terms in this group there was a rapid decrease in the content of MDA. By its nature, the dynamics of API in animals of the experimental group of animals, which received according to the conditions of the experiment, the appropriate local treatment with the developed complex, differed markedly from the dynamics found in the control. At the end of the experiment (the10-th day), the API data completely coincided with the data same as of intact animals.
Conclusions. Topical application of the developed complex reduces the content of lipoperoxidation products, in particular the concentration of MDA, which avoids overexertion and depletion of antioxidant defense systems, resulting in a shift of balance in the antioxidant direction and its normalization on the 7th day.
Key words: ulcerative-necrotic gingivitis, experimental animals, API, MDA.
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